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HEXANE

MSDS Number: H2381 --- Effective Date: 12/09/96


1. Product Identification

Synonyms: Hexanes,Normal Hexane; Hexyl Hydride
CAS No.: 110-54-3 (n-hexane)
Molecular Weight: 86.18
Chemical Formula: CH3(CH2)4CH3 n-hexane
Product Codes: 9262, 9304, 9308, N168


2. Composition/Information on Ingredients


  Ingredient                                CAS No         Percent   Hazardous                                       
  ---------------------------------------   ------------   -------   ---------        
 
  Hexane                                    110-54-3       85 > 99%     Yes                                                                 
  Methylcyclopentane                        96-37-7         1 - 2%      Yes                                                                
  Trace amount of Benzene  (10 ppm)         071-43-2           *        No                                                               
 


3. Hazards Identification

Emergency Overview
--------------------------
DANGER! EXTREMELY FLAMMABLE LIQUID AND VAPOR. VAPOR MAY CAUSE FLASH FIRE. HARMFUL OR FATAL IF SWALLOWED. HARMFUL IF INHALED. CAUSES IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. AFFECTS THE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS.


J.T. Baker SAF-T-DATA(tm) Ratings (Provided here for your convenience)
-----------------------------------------------------------------------------------------------------------
Health Rating: 2 - Moderate
Flammability Rating: 3 - Severe (Flammable)
Reactivity Rating: 0 - None
Contact Rating: 2 - Moderate
Lab Protective Equip: GOGGLES; LAB COAT; VENT HOOD; PROPER GLOVES; CLASS B EXTINGUISHER
Storage Color Code: Red (Flammable)
-----------------------------------------------------------------------------------------------------------

Potential Health Effects
----------------------------------

The health hazards addressed are for the major component: n-hexane.

Inhalation:
Inhalation of vapors irritates the respiratory tract. Overexposure may cause lightheadedness, nausea, headache, and blurred vision. Greater exposure may cause muscle weakness, numbness of the extremities, unconsciousness and death.

Ingestion:
May produce abdominal pain, nausea. Aspiration into lungs can produce severe lung damage and is a medical emergency. Other symptoms expected to parallel inhalation.

Skin Contact:
May cause redness, irritation, with dryness, cracking.

Eye Contact:
Vapors may cause irritation. Splashes may cause redness and pain.

Chronic Exposure:
Repeated or prolonged skin contact may defat the skin and produce irritation and dermatitis. Chronic inhalation may cause peripheral nerve disorders and central nervous system effects.

Aggravation of Pre-existing Conditions:
Persons with pre-existing skin disorders or eye problems or impaired respiratory function may be more susceptible to the effects of the substance. May affect the developing fetus.


4. First Aid Measures

Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a physician.

Ingestion:
Aspiration hazard. If swallowed, DO NOT INDUCE VOMITING. Give large quantities of water. Never give anything by mouth to an unconscious person. Get medical attention immediately.

Skin Contact:
Remove any contaminated clothing. Wipe off excess from skin. Wash skin with soap and water for at least 15 minutes. Get medical attention if irritation develops or persists.

Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

Note to Physician:
BEI=2,5-hexadione in urine, sample at end of shift at workweeks end, 5 mg/g creatine. Also, measure n-hexane in expired air. Analgesics may be necessary for pain management, there is no specific antidote. Monitor arterial blood gases in cases of severe aspiration.


5. Fire Fighting Measures

Fire:
Flash point: -23C (-9F) CC Autoignition temperature: 224C (435F) Flammable limits in air % by volume: lel: 1.2; uel: 7.7 Extremely Flammable Liquid and Vapor! Vapor may cause flash fire. Dangerous fire hazard when exposed to heat or flame.

Explosion:
Above flash point, vapor-air mixtures are explosive within flammable limits noted above. Contact with oxidizing materials may cause extremely violent combustion.Explodes when mixed @ 28C with dinitrogen tetraoxide. Sensitive to static discharge.

Fire Extinguishing Media:
Dry chemical, foam or carbon dioxide. Water may be ineffective.

Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode. Water spray may be used to keep fire exposed containers cool. Vapors can flow along surfaces to distant ignition source and flash back. Vapor explosion hazard exists indoors, outdoors, or in sewers.


6. Accidental Release Measures

Ventilate area of leak or spill. Remove all sources of ignition. Wear appropriate personal protective equipment as specified in Section 8. Isolate hazard area. Keep unnecessary and unprotected personnel from entering. Contain and recover liquid when possible. Use non-sparking tools and equipment. Collect liquid in an appropriate container or absorb with an inert material (e. g., vermiculite, dry sand, earth), and place in a chemical waste container. Do not use combustible materials, such as saw dust. Do not flush to sewer! If a leak or spill has not ignited, use water spray to disperse the vapors, to protect personnel attempting to stop leak, and to flush spills away from exposures. US Regulations (CERCLA) require reporting spills and releases to soil, water and air in excess of reportable quantities. The toll free number for the US Coast Guard National Response Center is (800) 424-8802. J. T. Baker SOLUSORB(tm) solvent adsorbent is recommended for spills of this product.


7. Handling and Storage

Protect against physical damage. Store in a cool, dry well-ventilated location, away from direct sunlight and any area where the fire hazard may be acute. Store in tightly closed containers (preferably under nitrogen atmosphere). Outside or detached storage is preferred. Inside storage should be in a standard flammable liquids storage room or cabinet. Separate from oxidizing materials. Containers should be bonded and grounded for transfers to avoid static sparks. Storage and use areas should be No Smoking areas. Use non-sparking type tools and equipment. Containers of this material may be hazardous when empty since they retain product residues (vapors, liquid); observe all warnings and precautions listed for the product.


8. Exposure Controls/Personal Protection

Airborne Exposure Limits:
N-Hexane [110-54-3]: -OSHA Permissible Exposure Limit (PEL): 500 ppm (TWA) -ACGIH Threshold Limit Value (TLV): 50 ppm (TWA) other isomers of hexane -ACGIH Threshold Limit Value (TLV): 500 ppm (TWA),1000ppm (STEL)

Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.

Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded, wear a supplied air, full-facepiece respirator, airlined hood, or full-facepiece self-contained breathing apparatus. This substance has poor warning properties.

Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.

Eye Protection:
Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.


9. Physical and Chemical Properties

Appearance:
Clear, colorless liquid.

Odor:
Light odor.

Solubility:
Insoluble in water.

Specific Gravity:
0.66

pH:
No information found.

% Volatiles by volume @ 21C (70F):
100

Boiling Point:
ca. 68C (ca. 154F)

Melting Point:
ca. -95C (ca. -139F)

Vapor Density (Air=1):
3.0

Vapor Pressure (mm Hg):
130 @ 20C (68F)

Evaporation Rate (BuAc=1):
9


10. Stability and Reactivity

Stability:
Stable under ordinary conditions of use and storage. Heat will contribute to instability.

Hazardous Decomposition Products:
May produce acrid smoke and irritating fumes when heated to decomposition.

Hazardous Polymerization:
Will not occur.

Incompatibilities:
Strong oxidizers.

Conditions to Avoid:
Heat, flames, ignition sources and incompatibles.


11. Toxicological Information


N-Hexane: Oral rat LD50: 28710 mg/kg. Irritation eye rabbit: 10 mg mild. Investigated as a tumorigen, mutagen and reproductive effector.

  --------\Cancer Lists\------------------------------------------------------
                                         ---NTP Carcinogen---
  Ingredient                             Known    Anticipated    IARC Category
  ------------------------------------   -----    -----------    -------------
  Trace amount of Benzene  (10 ppm)       Yes         No              1
  (071-43-2)                          
  Hexane (110-54-3)                       No          No            None
  Methylcyclopentane (96-37-7)            No          No            None


12. Ecological Information

Environmental Fate:
When released into the soil, this material may biodegrade to a moderate extent. When released into the soil, this material is not expected to leach into groundwater. When released into the soil, this material is expected to quickly evaporate. When released into water, this material may biodegrade to a moderate extent. When released to water, this material is expected to quickly evaporate. When released into the water, this material is expected to have a half-life between 1 and 10 days. This material has an estimated bioconcentration factor (BCF) of less than 100. This material has a log octanol-water partition coefficient of greater than 3.0. This material is not expected to significantly bioaccumulate. When released into the air, this material is expected to be readily degraded by reaction with photochemically produced hydroxyl radicals. When released into the air, this material is expected to have a half-life between 1 and 10 days.

Environmental Toxicity:
No information found.


13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be handled as hazardous waste and sent to a RCRA approved incinerator or disposed in a RCRA approved waste facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.


14. Transport Information

Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: HEXANES
Hazard Class: 3
UN/NA: UN1208
Packing Group: II
Information reported for product/size: 215L

International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: HEXANES
Hazard Class: 3.1
UN/NA: UN1208
Packing Group: II
Information reported for product/size: 215L



15. Regulatory Information


  --------\Chemical Inventory Status - Part 1\---------------------------------
  Ingredient                                       TSCA  EC   Japan  Australia
  -----------------------------------------------  ----  ---  -----  ---------
  Trace amount of Benzene  (10 ppm) (071-43-2)      Yes  Yes   Yes      Yes                                      
  Hexane (110-54-3)                                 Yes  Yes   Yes      Yes                                      
  Methylcyclopentane (96-37-7)                      Yes  Yes   No       Yes                                      
 
  --------\Chemical Inventory Status - Part 2\---------------------------------
                                                          --Canada--
  Ingredient                                       Korea  DSL   NDSL  Phil.
  -----------------------------------------------  -----  ---   ----  -----
  Trace amount of Benzene  (10 ppm) (071-43-2)      Yes   Yes   No     Yes                             
  Hexane (110-54-3)                                 Yes   Yes   No     Yes                             
  Methylcyclopentane (96-37-7)                      Yes   Yes   No     Yes                             
 
  --------\Federal, State & International Regulations - Part 1\----------------
                                             -SARA 302-    ------SARA 313------
  Ingredient                                 RQ    TPQ     List  Chemical Catg.
  -----------------------------------------  ---   -----   ----  --------------
  Trace amount of Benzene  (10 ppm)          No    No      Yes        No
  (071-43-2)                                  
  Hexane (110-54-3)                          No    No      Yes        No
  Methylcyclopentane (96-37-7)               No    No      No         No
 
  --------\Federal, State & International Regulations - Part 2\----------------
                                                        -RCRA-    -TSCA-
  Ingredient                                 CERCLA     261.33     8(d) 
  -----------------------------------------  ------     ------    ------
  Trace amount of Benzene  (10 ppm)          10         U019       No             
  (071-43-2)                              
  Hexane (110-54-3)                          5000       No         No                   
  Methylcyclopentane (96-37-7)               No         No         No                   
 
 
Chemical Weapons Convention:  No     TSCA 12(b):  No     CDTA:  No
SARA 311/312:  Acute: Yes      Chronic: Yes  Fire: Yes Pressure: No
Reactivity: No          (Mixture / Liquid)
Prop 65:
THIS PRODUCT CONTAINS A CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE CANCER.

Australian Hazchem Code: 3[Y]E
Poison Schedule: No information found.

WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.


16. Other Information

NFPA Ratings: Health: 1 Flammability: 3 Reactivity: 0

Label Hazard Warning:
DANGER! EXTREMELY FLAMMABLE LIQUID AND VAPOR. VAPOR MAY CAUSE FLASH FIRE. HARMFUL OR FATAL IF SWALLOWED. HARMFUL IF INHALED. CAUSES IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. AFFECTS THE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS.

Label Precautions:
Keep away from heat, sparks and flame. Keep container closed. Use only with adequate ventilation. Wash thoroughly after handling. Avoid breathing vapor or mist. Avoid contact with eyes, skin and clothing.

Label First Aid:
Aspiration hazard. If swallowed, vomiting may occur spontaneously, but DO NOT INDUCE. If vomiting occurs, keep head below hips to prevent aspiration into lungs. Never give anything by mouth to an unconscious person. Call a physician immediately. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes. In all cases call a physician.

Product Use:
Laboratory Reagent.

Revision Information:
Mixture. New 16 section MSDS format, all sections have been revised.

Disclaimer:
************************************************************************************************ Mallinckrodt Baker, Inc. provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. MALLINCKRODT BAKER, INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT BAKER, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
************************************************************************************************ Prepared by: Strategic Services Division
Phone Number: (314) 539-1600 (U.S.A.)