ACETIC ANHYDRIDE
MSDS Number: A0338 --- Effective Date: 03/05/97
1. Product Identification
Synonyms: Acetyl oxide; Acetic acid anhydride; Acetic oxide;
Ethanoic anhydride
CAS No.: 108-24-7
Molecular Weight: 102.09
Chemical Formula: (CH3CO)2O
Product Codes: J.T. Baker:
0018
Mallinckrodt:
2420
2. Composition/Information on Ingredients
Ingredient CAS No Percent Hazardous
--------------------------------------- ------------ ------- ---------
Acetic Anhydride 108-24-7 97 - 100% Yes
3. Hazards Identification
Emergency Overview
--------------------------
DANGER! CORROSIVE. CAUSES BURNS TO ANY AREA OF CONTACT. FLAMMABLE LIQUID
AND VAPOR. WATER REACTIVE. HARMFUL IF SWALLOWED OR INHALED. VAPOR CAUSES
RESPIRATORY TRACT IRRITATION AND SEVERE EYE IRRITATION.
J.T. Baker SAF-T-DATA(tm) Ratings (Provided here for your convenience)
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Health Rating: 3 - Severe (Poison)
Flammability Rating: 2 - Moderate
Reactivity Rating: 2 - Moderate
Contact Rating: 3 - Severe (Corrosive)
Lab Protective Equip: GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPER
GLOVES; CLASS B EXTINGUISHER
Storage Color Code: Red Stripe (Store Separately)
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Potential Health Effects
----------------------------------
Inhalation:
Vapors are corrosive to the mucous membranes of the upper respiratory
tract. Exposure to vapors may cause irritation of the nose, throat, and
coughing. Exposure to high concentrations may result in severe damage to
the lungs. Symptoms of lung edema are often delayed and are aggravated by
physical effort.
Ingestion:
Corrosive. Causes a burning pain in the stomach, followed by nausea and
vomiting.
Skin Contact:
Corrosive: Does not cause severe burning on contact but can cause delayed
reaction burns. If not removed by washing, the skin may become reddened and
later turn white and wrinkled. Continued skin contact may cause dermatitis.
Eye Contact:
Corrosive: Contact with the liquid or vapor may produce a burning sensation
and tearing. Redness, pain and blurred vision may be followed by permanent
eye damage. The appearance of eye burns may be delayed. Irritation effects
begin with airborne concentrations as low as 0.36 mg/m3.
Chronic Exposure:
Repeated and prolonged exposure to vapor may cause irritation of the skin
and chronic eye irritation.
Aggravation of Pre-existing Conditions:
Persons with pre-existing skin disorders or eye problems, or impaired
respiratory function may be more susceptible to the effects of the
substance.
4. First Aid Measures
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Get medical attention immediately.
Ingestion:
If swallowed, DO NOT INDUCE VOMITING. Give large quantities of water. Never
give anything by mouth to an unconscious person. Get medical attention
immediately.
Skin Contact:
Immediately flush skin with plenty of water for at least 15 minutes while
removing contaminated clothing and shoes. Get medical attention
immediately. Wash clothing before reuse. Thoroughly clean shoes before
reuse.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes,
lifting lower and upper eyelids occasionally. Get medical attention
immediately.
5. Fire Fighting Measures
Fire:
Flash point: 49C (120F) CC
Autoignition temperature: 316C (601F)
Flammable limits in air % by volume:
lel: 2.7; uel: 10.3
Flammable.
Explosion:
Above flash point, vapor-air mixtures are explosive within flammable limits
noted above. Sealed containers may rupture when heated. Vapors can flow
along surfaces to distant ignition source and flash back. A violent
exothermic reaction occurs with water. Sufficient heat may be produced to
ignite combustible materials. Sensitive to static discharge.
Fire Extinguishing Media:
Water spray, dry chemical, alcohol foam, or carbon dioxide. Use water with
caution as material reacts with water.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved
self-contained breathing apparatus with full facepiece operated in the
pressure demand or other positive pressure mode. Use water spray to blanket
fire, cool fire exposed containers, and to flush non-ignited spills or
vapors away from fire.
6. Accidental Release Measures
Ventilate area of leak or spill. Wear appropriate personal protective
equipment as specified in Section 8. Isolate hazard area. Keep unnecessary
and unprotected personnel from entering. Water spray may be used to
disperse vapors and dilute spills to nonflammable mixtures, but be aware of
the potential for violent reaction with water. Neutralize with soda ash or
lime. Contain and recover liquid when possible. Collect liquid in an
appropriate container or absorb with an inert material (e. g., vermiculite,
dry sand, earth), and place in a chemical waste container. Do not use
combustible materials, such as saw dust. Do not flush to sewer! US
Regulations (CERCLA) require reporting spills and releases to soil, water
and air in excess of reportable quantities. The toll free number for the US
Coast Guard National Response Center is (800) 424-8802.
7. Handling and Storage
Protect against physical damage. Store in a cool, dry well-ventilated
location, away from any area where the fire hazard may be acute. Outside or
detached storage is preferred. Separate from incompatibles. Containers
should be bonded and grounded for transfers to avoid static sparks. Storage
and use areas should be No Smoking areas. Use non-sparking type tools and
equipment, including explosion proof ventilation. Keep away from water.
This material is corrosive to steel, galvanized iron, copper and copper
alloys. Containers of this material may be hazardous when empty since they
retain product residues (vapors, liquid); observe all warnings and
precautions listed for the product.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
-OSHA Permissible Exposure Limit (PEL):
5 ppm (TWA)
-ACGIH Threshold Limit Value (TLV):
5 ppm (TWA)
-NIOSH Recommended Exposure Limit (REL):
5 ppm (Ceiling)
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee
exposures below the Airborne
Exposure Limits. Local exhaust ventilation is generally preferred because
it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH
document, Industrial Ventilation, A Manual of Recommended Practices,
most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded, a full facepiece respirator with organic
vapor cartridge may be worn up to 50 times the exposure limit or the
maximum use concentration specified by the appropriate regulatory agency or
respirator supplier, whichever is lowest. For emergencies or instances
where the exposure levels are not known, use a full-facepiece
positive-pressure, air-supplied respirator. WARNING: Air purifying
respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat,
apron or coveralls, as appropriate, to prevent skin contact. Rubber and
neoprene are recommended materials for personal protective equipment.
Eye Protection:
Use chemical safety goggles and/or a full face shield where splashing is
possible. Maintain eye wash fountain and quick-drench facilities in work
area.
9. Physical and Chemical Properties
Appearance:
Clear, colorless liquid.
Odor:
Strong acetic odor; good warning properties.
Solubility:
Slowly soluble in water (reacts)
Specific Gravity:
1.08 @ 15C/4C
pH:
No information found.
% Volatiles by volume @ 21C (70F):
100
Boiling Point:
140C (284F)
Melting Point:
-73C (-99F)
Vapor Density (Air=1):
3.52
Vapor Pressure (mm Hg):
4 @ 20C (68F)
Evaporation Rate (BuAc=1):
0.46
10. Stability and Reactivity
Stability:
Stable under ordinary conditions of use and storage. Heat will contribute
to instability.
Hazardous Decomposition Products:
When heated to decomposition, it emits toxic fumes such as acetic acid and
carbon monoxide. Reacts violently with water to yield acetic acid and much
heat.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Water, steam, mineral acids, oxidizing materials, alcohols, or amines may
cause violent reaction. Contact with strong caustics will cause violent
reaction and spattering. Corrosive to copper, brass, bronze, and iron.
Conditions to Avoid:
Heat, flames, ignition sources, water and incompatibles.
11. Toxicological Information
Oral rat LD50: 1780 mg/Kg; inhalation rat LC50: 1000 ppm/4-hour; skin
rabbit LD50 4 mL/kg; Irritation data: Skin rabbit, Open Draize, 10 mg/24H
mild; Eye rabbit, Open Draize, 250 ug severe
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
Acetic Anhydride (108-24-7) No No None
12. Ecological Information
Environmental Fate:
When released into the soil, this material is expected to leach into
groundwater. When released to water, this material is expected to react and
form acetic acid. This material is not expected to significantly
bioaccumulate.
Environmental Toxicity:
No information found.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be handled as
hazardous waste and sent to a RCRA approved waste facility. Processing, use
or contamination of this product may change the waste management options.
State and local disposal regulations may differ from federal disposal
regulations.
Dispose of container and unused contents in accordance with federal, state
and local requirements.
14. Transport Information
Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: ACETIC ANHYDRIDE
Hazard Class: 8, 3
UN/NA: UN1715
Packing Group: II
Information reported for product/size: 40LB
International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: ACETIC ANHYDRIDE
Hazard Class: 8, 3.3
UN/NA: UN1715
Packing Group: II
Information reported for product/size: 40LB
International (Air, I.C.A.O.)
-----------------------------
Proper Shipping Name: ACETIC ANHYDRIDE
Hazard Class: 8, 3
UN/NA: UN1715
Packing Group: II
Information reported for product/size: 40LB
15. Regulatory Information
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
Acetic Anhydride (108-24-7) Yes Yes Yes Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
Acetic Anhydride (108-24-7) Yes Yes No Yes
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
Acetic Anhydride (108-24-7) No No No No
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
Acetic Anhydride (108-24-7) 5000 No No
Chemical Weapons Convention: No TSCA 12(b): No CDTA: Yes
SARA 311/312: Acute: Yes Chronic: Yes Fire: Yes Pressure: No
Reactivity: Yes (Pure / Liquid)
Australian Hazchem Code: 2P
Poison Schedule: S6
WHMIS:
This MSDS has been prepared according to the hazard criteria of
the Controlled Products Regulations (CPR) and the MSDS contains
all of the information required by the CPR.
16. Other Information
NFPA Ratings:
Health: 3 Flammability: 2 Reactivity: 1
Label Hazard Warning:
DANGER! CORROSIVE. CAUSES BURNS TO ANY AREA OF CONTACT. FLAMMABLE LIQUID AND
VAPOR. WATER REACTIVE. HARMFUL IF SWALLOWED OR INHALED. VAPOR CAUSES
RESPIRATORY TRACT IRRITATION AND SEVERE EYE IRRITATION.
Label Precautions:
Do not get in eyes, on skin, or on clothing.
Do not contact with water.
Do not breathe vapor.
Keep container closed.
Use only with adequate ventilation.
Wash thoroughly after handling.
Keep away from heat, sparks and flame.
Label First Aid:
In case of contact, immediately flush eyes or skin with plenty of water for
at least 15 minutes while removing contaminated clothing and shoes. Wash
clothing before reuse. If inhaled, remove to fresh air. If not breathing,
give artificial respiration. If breathing is difficult, give oxygen. If
swallowed, DO NOT INDUCE VOMITING. Give large quantities of water. Never give
anything by mouth to an unconscious person. In all cases get medical
attention immediately.
Product Use:
Laboratory Reagent.
Revision Information:
Pure. New 16 section MSDS format, all sections have been revised.
Disclaimer:
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Mallinckrodt Baker, Inc. provides the information contained herein in good
faith but makes no representation as to its comprehensiveness or accuracy. This
document is intended only as a guide to the appropriate precautionary handling
of the material by a properly trained person using this product. Individuals
receiving the information must exercise their independent judgment in
determining its appropriateness for a particular purpose. MALLINCKRODT BAKER,
INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED,
INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A
PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE
PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT BAKER, INC.
WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS
INFORMATION.
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Prepared by: Strategic Services Division
Phone Number: (314) 539-1600 (U.S.A.)